Groulx T, Bagshawe M, Giesbrecht G, Tomfohr-Madsen L, Hetherington E, Lebel CA. Prenatal care disruptions and associations with maternal mental health during the COVID-19 Pandemic. Front Glob Womens Health. 2021;2:648428 https://doi.org/10.3389/fgwh.2021.648428.
Google Scholar
Public Health Agency of Canada. Pregnancy, childbirth and caring for newborns: advice for mothers during COVID-19 2020. Accessed 26 May 2023.
Urrutia D, Manetti E, Williamson M, Lequy E. Overview of Canada’s answer to the COVID-19 pandemic’s first wave (January–April 2020). Int J Env Res Public Health. 2021;18:7131.
Google Scholar
Chmielewska B, Barratt I, Townsend R, Kalafat E, van der Meulen J, Gurol-Urganci I, et al. Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis. Lancet Glob Health. 2021;9:e759–72. https://doi.org/10.1016/S2214-109X(21)00079-6.
Google Scholar
Lebel C, MacKinnon A, Bagshawe M, Tomfohr-Madsen L, Giesbrecht G. Elevated depression and anxiety symptoms among pregnant individuals during the COVID-19 pandemic. J Affect Disord. 2020;277:5–13. https://doi.org/10.1016/j.jad.2020.07.126.
Google Scholar
Mateus V, Cruz S, Costa R, Mesquita A, Christoforou A, Wilson CA, et al. Rates of depressive and anxiety symptoms in the perinatal period during the COVID-19 pandemic: comparisons between countries and with pre-pandemic data. J Affect Disord. 2022;316:245–53.
Google Scholar
Papadopoulos A, Nichols ES, Mohsenzadeh Y, Giroux I, Mottola MF, Van Lieshout RJ, et al. Depression in pregnant women with and without COVID-19. BJPsych Open. 2021;7:e173.
Google Scholar
Gunnar MR, Doyle C The effects of prenatal stress on offspring development. Wiley Encycl Health Psychol. 2020:275–86. https://doi.org/10.1002/9781119057840.ch32.
Lautarescu A, Craig MC, Glover V. Prenatal stress: effects on fetal and child brain development. Int Rev Neurobiol. 2020;150:17–40. https://doi.org/10.1016/bs.irn.2019.11.002.
Google Scholar
Papadopoulos A, Nichols ES, Mohsenzadeh Y, Giroux I, Mottola MF, Van Lieshout RJ, et al. Prenatal and postpartum maternal mental health and neonatal motor outcomes during the COVID-19 pandemic. J Affect Disord Rep. 2022;10:100387.
Google Scholar
Van den Bergh BR, van den Heuvel MI, Lahti M, Braeken M, de Rooij SR, Entringer S, et al. Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy. Neurosci Biobehav Rev. 2020;117:26–64.
Google Scholar
Falah-Hassani K, Shiri R, Dennis C-L. The prevalence of antenatal and postnatal co-morbid anxiety and depression: a meta-analysis. Psychol Med. 2017;47:2041–53.
Google Scholar
American Psychiatric Association issuing body. Diagnostic and statistical manual of mental disorders: DSM-5-TR. 5th edition, text revision. Washington, DC: American Psychiatric Association Publishing;2022.
Yang Z, Wang X, Wang M, Yan S, Wu F, Zhang F. Trajectory of prenatal anxiety and depression and its association with fetal growth development. Early Hum Dev. 2023;187:105875.
Google Scholar
Austin M-P, Hadzi-Pavlovic D, Leader L, Saint K, Parker G. Maternal trait anxiety, depression and life event stress in pregnancy: relationships with infant temperament. Early Hum Dev. 2005;81:183–90.
Google Scholar
Bergman K, Sarkar P, O’Connor TG, Modi N, Glover V. Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. J Am Acad Child Adolesc Psychiatry. 2007;46:1454–63.
Google Scholar
Field T. Prenatal anxiety effects: a review. Infant Behav Dev. 2017;49:120–8.
Google Scholar
Field T. Prenatal depression effects on early development: a review. Infant Behav Dev. 2011;34:1–14.
Google Scholar
Laplante DP, Brunet A, King S. The effects of maternal stress and illness during pregnancy on infant temperament: Project Ice Storm. Pediatr Res. 2016;79:107–13.
Google Scholar
Simcock G, Elgbeili G, Laplante DP, Kildea S, Cobham V, Stapleton H, et al. The effects of prenatal maternal stress on early temperament: the 2011 Queensland Flood Study. J Dev Behav Pediatr. 2017;38:310–21.
Google Scholar
Simcock G, Laplante DP, Elgbeili G, Kildea S, Cobham V, Stapleton H, et al. Infant neurodevelopment is affected by prenatal maternal stress: the QF 2011 Queensland Flood Study. Infancy. 2017;22:282–302.
Google Scholar
King S, Dancause K, Turcotte‐Tremblay A, Veru F, Laplante DP. Using natural disasters to study the effects of prenatal maternal stress on child health and development. Birth Defects Res Part C Embryo Today Rev. 2012;96:273–88.
Google Scholar
Fuster JM. Frontal lobe and cognitive development. J Neurocytol. 2002;31:373–85.
Google Scholar
Seymour B, Dolan R. Emotion, decision making, and the amygdala. Neuron. 2008;58:662–71.
Google Scholar
Tottenham N, Gabard-Durnam LJ. The developing amygdala: a student of the world and a teacher of the cortex. Curr Opin Psychol. 2017;17:55–60.
Google Scholar
Lehtola SJ, Tuulari JJ, Scheinin NM, Karlsson L, Parkkola R, Merisaari H, et al. Newborn amygdalar volumes are associated with maternal prenatal psychological distress in a sex-dependent way. NeuroImage Clin. 2020;28:102380.
Google Scholar
Buss C, Davis EP, Shahbaba B, Pruessner JC, Head K, Sandman CA. Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proc Natl Acad Sci. 2012;109:E1312–9.
Google Scholar
Wen D, Poh J, Ni S, Chong Y, Chen H, Kwek K, et al. Influences of prenatal and postnatal maternal depression on amygdala volume and microstructure in young children. Transl Psychiatry. 2017;7:e1103.
Google Scholar
Jones SL, Dufoix R, Laplante DP, Elgbeili G, Patel R, Chakravarty MM, et al. Larger amygdala volume mediates the association between prenatal maternal stress and higher levels of externalizing behaviors: sex specific effects in project ice storm. Front Hum Neurosci. 2019;13:144.
Google Scholar
Rifkin-Graboi A, Bai J, Chen H, Hameed WB, Sim LW, Tint MT, et al. Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth. Biol Psychiatry. 2013;74:837–44.
Google Scholar
Rosso IM, Cintron CM, Steingard RJ, Renshaw PF, Young AD, Yurgelun-Todd DA. Amygdala and hippocampus volumes in pediatric major depression. Biol Psychiatry. 2005;57:21–6.
Google Scholar
Warnell KR, Pecukonis M, Redcay E. Developmental relations between amygdala volume and anxiety traits: Effects of informant, sex, and age. Dev Psychopathol. 2018;30:1503–15.
Google Scholar
Albaugh MD, Nguyen T-V, Ducharme S, Collins DL, Botteron KN, D’Alberto N, et al. Age-related volumetric change of limbic structures and subclinical anxious/depressed symptomatology in typically developing children and adolescents. Biol Psychol. 2017;124:133–40.
Google Scholar
De Bellis MD, Casey B, Dahl RE, Birmaher B, Williamson DE, Thomas KM, et al. A pilot study of amygdala volumes in pediatric generalized anxiety disorder. Biol Psychiatry. 2000;48:51–7.
Google Scholar
Grossmann T. Mapping prefrontal cortex functions in human infancy. Infancy. 2013;18:303–24.
Teffer K, Semendeferi K. Human prefrontal cortex: evolution, development, and pathology. Prog Brain Res. 2012;195:191–218. https://doi.org/10.1016/B978-0-444-53860-4.00009-X.
Google Scholar
Buss C, Davis EP, Muftuler LT, Head K, Sandman CA. High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6–9-year-old children. Psychoneuroendocrinology. 2010;35:141–53.
Google Scholar
Sandman CA, Buss C, Head K, Davis EP. Fetal exposure to maternal depressive symptoms is associated with cortical thickness in late childhood. Biol Psychiatry. 2015;77:324–34. https://doi.org/10.1016/j.biopsych.2014.06.025.
Google Scholar
Hogstrom LJ, Westlye LT, Walhovd KB, Fjell AM. The structure of the cerebral cortex across adult life: age-related patterns of surface area, thickness, and gyrification. Cereb Cortex. 2013;23:2521–30.
Google Scholar
Kolk SM, Rakic P. Development of prefrontal cortex. Neuropsychopharmacology. 2022;47:41–57.
Google Scholar
Lyall AE, Shi F, Geng X, Woolson S, Li G, Wang L, et al. Dynamic development of regional cortical thickness and surface area in early childhood. Cereb Cortex. 2015;25:2204–12.
Google Scholar
Belleau EL, Treadway MT, Pizzagalli DA. The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology. Biol Psychiatry. 2019;85:443–53.
Google Scholar
Yuan P, Raz N. Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies. Neurosci Biobehav Rev. 2014;42:180–92.
Google Scholar
Gosnell SN, Velasquez KM, Molfese DL, Molfese PJ, Madan A, Fowler JC, et al. Prefrontal cortex, temporal cortex, and hippocampus volume are affected in suicidal psychiatric patients. Psychiatry Res Neuroimaging. 2016;256:50–6.
Google Scholar
Ohtani T, Levitt JJ, Nestor PG, Kawashima T, Asami T, Shenton ME, et al. Prefrontal cortex volume deficit in schizophrenia: a new look using 3 T MRI with manual parcellation. Schizophr Res. 2014;152:184–90.
Google Scholar
Lagopoulos J, Hermens DF, Naismith SL, Scott EM, Hickie IB. Frontal lobe changes occur early in the course of affective disorders in young people. BMC Psychiatry. 2012;12:1–7.
Glover V, Bergman K, Sarkar P, O’Connor TG. Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety. Psychoneuroendocrinology. 2009;34:430–5.
Google Scholar
Tottenham N, Sheridan MA. A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing. Front Hum Neurosci. 2010;3:68.
Google Scholar
Buthmann JL, Miller JG, Gotlib IH. Maternal–prenatal stress and depression predict infant temperament during the COVID-19 pandemic. Dev Psychopathol. 2022;36:161–9.
Google Scholar
Manning KY, Long X, Watts D, Tomfohr-Madsen L, Giesbrecht GF, Lebel C. Prenatal maternal distress during the COVID-19 pandemic and associations with infant brain connectivity. Biol Psychiatry. 2022;92:701–8.
Google Scholar
Duguay G, Garon-Bissonnette J, Lemieux R, Dubois-Comtois K, Mayrand K, Berthelot N. Socioemotional development in infants of pregnant women during the COVID-19 pandemic: the role of prenatal and postnatal maternal distress. Child Adolesc Psychiatry Ment Health. 2022;16:28.
Google Scholar
Giesbrecht GF, Lebel C, Dennis C-L, Silang K, Xie EB, Tough S, et al. Risk for developmental delay among infants born during the COVID-19 pandemic. J Dev Behav Pediatr. 2023;44:e412–20.
Google Scholar
Hessami K, Norooznezhad AH, Monteiro S, Barrozo ER, Abdolmaleki AS, Arian SE, et al. COVID-19 pandemic and infant neurodevelopmental impairment: a systematic review and meta-analysis. JAMA Netw Open. 2022;5:e2238941–e2238941.
Google Scholar
Morris AR, Saxbe DE. Differences in infant negative affectivity during the COVID‐19 pandemic. Infant Ment Health J. 2023;44:466–79.
Google Scholar
Giesbrecht GF, Bagshawe M, van Sloten M, MacKinnon AL, Dhillon A, van de Wouw M, et al. Protocol for the pregnancy during the COVID-19 pandemic (PdP) study: a longitudinal cohort study of mental health among pregnant Canadians during the COVID-19 pandemic and developmental outcomes in their children. JMIR Res Protoc. 2021;10:e25407.
Google Scholar
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inf. 2009;42:377–81.
Giesbrecht G, van de Wouw M, Rioux C, Lai B, King S, Tomfohr-Madsen L, et al. Cumulative and compounding effects of pre-pandemic vulnerabilities and pandemic-related hardship on psychological distress among pregnant individuals. Gen Hosp Psychiatry. 2023;83:93–100.
Google Scholar
Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385–96.
Google Scholar
Lee E-H. Review of the psychometric evidence of the perceived stress scale. Asian Nurs Res. 2012;6:121–7.
Murray D, Cox JL. Screening for depression during pregnancy with the Edinburgh Depression Scale (EDDS). J Reprod Infant Psychol. 1990;8:99–107.
Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression: development of the 10-item Edinburgh postnatal depression scale. Br J Psychiatry. 1987;150:782–6.
Google Scholar
Cox JL, Chapman G, Murray D, Jones P. Validation of the Edinburgh Postnatal Depression Scale (EPDS) in non-postnatal women. J Affect Disord. 1996;39:185–9.
Google Scholar
Pilkonis PA, Choi SW, Reise SP, Stover AM, Riley WT, Cella D, et al. Item banks for measuring emotional distress from the Patient-Reported Outcomes Measurement Information System (PROMIS®): depression, anxiety, and anger. Assessment. 2011;18:263–83.
Google Scholar
Cella D, Riley W, Stone A, Rothrock N, Reeve B, Yount S, et al. The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005–2008. J Clin Epidemiol. 2010;63:1179–94.
Google Scholar
Gartstein MA, Rothbart MK. Studying infant temperament via the revised infant behavior questionnaire. Infant Behav Dev. 2003;26:64–86.
Putnam SP, Helbig AL, Gartstein MA, Rothbart MK, Leerkes E. Development and assessment of short and very short forms of the Infant Behavior Questionnaire–revised. J Pers Assess. 2014;96:445–58.
Google Scholar
Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002;33:341–55.
Google Scholar
Rajkowska G, Goldman-Rakic PS. Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the talairach coordinate system. Cereb Cortex. 1995;5:323–37.
Google Scholar
Putnam SP, Sehic E, French BF, Gartstein MA, Lira Luttges B. The global temperament project: parent-reported temperament in infants, toddlers, and children from 59 nations. Dev Psychol. 2024.
Hayes AF. Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. Guilford publications; New York, NY, 2017.
Acosta H, Tuulari JJ, Scheinin NM, Hashempour N, Rajasilta O, Lavonius TI, et al. Maternal pregnancy-related anxiety is associated with sexually dimorphic alterations in amygdala volume in 4-year-old children. Front Behav Neurosci. 2019;13:175.
Google Scholar
Russell JD, Marsee MA, Weems CF. Developmental variation in amygdala volumes: modeling differences across time, age, and puberty. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;6:117–25.
Google Scholar
Charil A, Laplante DP, Vaillancourt C, King S. Prenatal stress and brain development. Brain Res Rev. 2010;65:56–79.
Google Scholar
Donnici C, Long X, Reynolds J, Giesbrecht GF, Dewey D, Letourneau N, et al. Prenatal depressive symptoms and childhood development of brain limbic and default mode network structure. Hum Brain Mapp. 2023;44:2380–94.
Google Scholar
Manning KY, Jaffer A, Lebel C. Windows of opportunity: how age and sex shape the influence of prenatal depression on the child brain. Biol Psychiatry. 2024;97:227–47.
Google Scholar
Demers CH, Hankin BL, Hennessey E-MP, Haase MH, Bagonis MM, Kim SH, et al. Maternal adverse childhood experiences and infant subcortical brain volume. Neurobiol Stress. 2022;21:100487.
Google Scholar
Sammallahti S, Serdarevic F, Tiemeier H. Excessive crying, behavior problems, and amygdala volume: a study from infancy to adolescence. J Am Acad Child Adolesc Psychiatry. 2023;62:675–83.
Google Scholar
Filippi CA, Sachs JF, Phillips D, Winkler A, Gold AL, Leibenluft E, et al. Infant behavioral reactivity predicts change in amygdala volume 12 years later. Dev Cogn Neurosci. 2020;42:100776.
Google Scholar
Burrows CA, Lasch C, Gross J, Girault JB, Rutsohn J, Wolff JJ, et al. Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples. Dev Cogn Neurosci. 2024;65:101333.
Google Scholar
Milham MP, Nugent AC, Drevets WC, Dickstein DS, Leibenluft E, Ernst M, et al. Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation. Biol Psychiatry. 2005;57:961–6.
Google Scholar
Bezanson S, Nichols ES, Duerden EG. Postnatal maternal distress, infant subcortical brain macrostructure and emotional regulation. Psychiatry Res Neuroimaging. 2023;328:111577.
Google Scholar
Baas D, Aleman A, Kahn RS. Lateralization of amygdala activation: a systematic review of functional neuroimaging studies. Brain Res Rev. 2004;45:96–103.
Google Scholar
Andescavage NN, Du Plessis A, McCarter R, Serag A, Evangelou I, Vezina G, et al. Complex trajectories of brain development in the healthy human fetus. Cereb Cortex. 2017;27:5274–83.
Google Scholar
Chen L, Pan H, Tuan TA, Teh AL, MacIsaac JL, Mah SM, et al. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. Dev Psychopathol. 2015;27:137–50.
Google Scholar
Qiu A, Tuan TA, Ong ML, Li Y, Chen H, Rifkin-Graboi A, et al. COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology. Am J Psychiatry. 2015;172:163–72.
Google Scholar
Qiu A, Shen M, Buss C, Chong Y-S, Kwek K, Saw S-M, et al. Effects of antenatal maternal depressive symptoms and socio-economic status on neonatal brain development are modulated by genetic risk. Cereb Cortex. 2017;27:3080–92.
Google Scholar
Ong M, Tuan TA, Poh J, Teh AL, Chen L, Pan H, et al. Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome. Genes Brain Behav. 2019;18:e12576.
Google Scholar
Graham AM, Doyle O, Tilden EL, Sullivan EL, Gustafsson HC, Marr M, et al. Effects of maternal psychological stress during pregnancy on offspring brain development: considering the role of inflammation and potential for preventive intervention. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022;7:461–70.
Google Scholar
Humphreys KL, Camacho M, Roth MC, Estes EC. Prenatal stress exposure and multimodal assessment of amygdala–medial prefrontal cortex connectivity in infants. Dev Cogn Neurosci. 2020;46:100877.
Google Scholar
Posner J, Cha J, Roy A, Peterson B, Bansal R, Gustafsson H, et al. Alterations in amygdala–prefrontal circuits in infants exposed to prenatal maternal depression. Transl Psychiatry. 2016;6:e935–e935.
Google Scholar
Qiu A, Anh T, Li Y, Chen H, Rifkin-Graboi A, Broekman MM, et al. Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants. Transl Psychiatry. 2015;5:e508.
Google Scholar
Hill TL, Na X, Bellando J, Glasier CM, Ou X. Functional connectivity to the amygdala in the neonate is impacted by the maternal anxiety level during pregnancy. J Neuroimaging. 2025;35:e70004.
Google Scholar
Donnici C, Long X, Dewey D, Letourneau N, Landman B, Huo Y, et al. Prenatal and postnatal maternal anxiety and amygdala structure and function in young children. Sci Rep. 2021;11:4019.
Google Scholar
Hay RE, Reynolds JE, Grohs MN, Paniukov D, Giesbrecht GF, Letourneau N, et al. Amygdala-Prefrontal Structural Connectivity Mediates the Relationship between Prenatal Depression and Behavior in Preschool Boys. J Neurosci. 2020;40:6969–6977.
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